Cyclopiazonic Acid, Penicill 1PC X 5MG

Description General description A cell-permeable, reversible inhibitor of endoplasmic reticulum Ca2+-ATPase that releases Ca2+ from the same intracellular pools as thapsigargin. Mobilizes Ca2+ without increasing the levels of Ins(1,4,5)P3. Also known to inhibit sarcoplasmic reticular Ca2+-ATPase that is distinct from actomyosin ATPase. Bay K 8644 (Cat. No. 196878) can reverse the inhibitory effect of cyclopiazonic acid on the refilling of Ca2+ pools that have been depleted by repetitive stimulation with acetylcholine. A cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase that releases Ca2+ from the same intracellular pools as Thapsigargin (Cat. No. 586005). Inhibits Ca2+ uptake in cultured arterial smooth muscle cells (IC50 = 560 nM). Also known to inhibit sarcoplasmic reticular Ca2+-ATPase that is distinct from actomyosin ATPase. Packaging 5 mg in Alu drum Biochem/physiol Actions Cell permeable: yes Primary Target Ca2+ uptake in cultured arterial musclue cells Product does not compete with ATP. Reversible: yes Target IC50: 560 nM inhibiting Ca2+ uptake in cultured arterial smooth muscle cells Warning Toxicity: Toxic (F) Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Other Notes Badaoui, A., et al. 1995. J. Mol. Cell. Cardiol. 27, 2495. Elmoselli, A.B., et al. 1995. Mol. Cell. Biochem. 151, 149. Schaefer, A., et al. 1994. J. Biol. Chem.269, 8786. Demaurex, N., et al. 1992. J. Biol. Chem.267, 2318. Low, A.M., et al. 1992. Am. J. Physiol.262, H31. Kurebayashi, N., and Ogawa, Y. 1991. J. Muscle Res. Cell Motil.12, 355. Mason, M.J., et al. 1991. J. Biol. Chem.266, 20856. Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.; Description