Description_x000D_ Application_x000D_ Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell. Investigation on the effect of Paris Saponin I (PS I) on human gastric carcinoma cell growth (SGC7901 cells) have shown an elevated level cytoplasmic cytochrome c. Results are an inhibition of proliferation in SGC7901 cells by inducing mitochondria-dependent apoptosis through cytochrome c._x000D_ Packaging_x000D_ 1, 5 g in glass bottle_x000D_ 50, 100, 500 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ The ready interconversion of cytochrome c between ferrous and ferric states makes it an efficient biological electron carrier. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal link in the respiratory chain, it forms the essential electron-bridge between the respirable substrates and oxygen._x000D_ Preparation Note_x000D_ Prepared using TCA._x000D_ Other Notes_x000D_ View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.