Formyl Peptide Receptor-Like 1PC X 5MG

Description General description A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks ligand-mediated [Ca2+]i increase, ERK activation, and chemotactic migration of FPRL1-expressing RBL-2H3 cells at a concentration of 10 µM. Also inhibits Aβ42 peptide-induced superoxide generation and prevents its internalization in human macrophages. A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with the ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks the ligand activated [Ca2+]i increase, ERK activation and chemotactic migration of FPRL1-expressing RBL-2H3 cells at 10 µM. Further, inhibits Aβ42 peptide-induced superoxide generation and prevents its internalization in human macrophages. Packaging 5 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Primary Target Formyl Peptide Receptor-Like 1 (FPRL1) Product does not compete with ATP. Reversible: no Target IC50: 230 nM for FPRL1 Agonist Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Sequence H-Trp-Arg-Trp-Trp-Trp-Trp-CONH₂ Physical form Supplied as a trifluoroacetate salt. Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Other Notes Bae, Y.S., et al. 2004. J. Immunol.173, 607.; Description