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Description_x000D_
Amino Acid Sequence_x000D_
Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile_x000D_
Application_x000D_
GAP-27 has been used as a blocking peptide for Cx43 (connexin 43) gap junctions in FDC (follicular dendritic cells)-B cell cultures._x000D_
Packaging_x000D_
2 mg in glass bottle_x000D_
Biochem/physiol Actions_x000D_
GAP-27 shares homology with a region of extracellular loops of connexins, and hence, is thought to inhibit junctions formed by the connexins Cx32, Cx40 and Cx43. It highly hinders co-operative cell-cell interactions including the synergized beating of embryonic cardiomyocytes. This peptide reduces osteoclastic activity and survival rates. This peptide significantly reduces acetylcholine-mediated hyperpolarization of smooth muscle cells._x000D_
Inhibitor of gap junction signaling in endothelial cells.
- Related Categories Adhesion Molecules and Related Proteins, Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix Quality Level