Description_x000D_ Biochem/physiol Actions_x000D_ Hyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression._x000D_ These enzymes randomly cleave β-N-acetylhexosamine-[1→4] glycosidic bonds in hyaluronic acid, chondroitin, and chondroitin sulfates._x000D_ Unit Definition_x000D_ One unit will cause a change in % transmittance at 600 nm of 0.330 per minute at pH 5.35 at 37 °C in a 2.0 mL reaction mixture (45 minute assay)._x000D_ Preparation Note_x000D_ Prepared from aseptic filled solution of Type I-S._x000D_ Other Notes_x000D_ View more information on enzymes for complex carbohydrate analysis at www.sigma-aldrich.com/enzymeexplorer