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HYDROXYPROPYL-BETA-CYCLODEXTRIN, MS = 0.
Кат. №: 332593-5G
Производитель: Sigma-Aldrich
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HYDROXYPROPYL-BETA-CYCLODEXTRIN, MS = 0.
Кат. №: 332593-5G
Производитель: Sigma-Aldrich
Кол-во:
Цена по запросу
Товар оформляется под заказ
Кол-во:
Цена по запросу
Товар оформляется под заказ
Description
Application
2-Hydroxylpropyl-β-cyclodextrin (HP-β-CD) is a hydroxyalkyl derivative used as formulation vehicle. It increases water solubility of the drug for successful delivery of medical agents to a biological system.
HP-β-CD can be used:
• To increase the solubility of ropivacaine (RVC) upon complexation, which in turn enhances the pharmacological activity of RVC.
• To increase the aqueous solubility of naproxen (NAP) in presence of polyvinylpyrrolidone (PVP.
• As a template in the synthesis of hollow spherical copper sulfide nanoparticle assemblies.
The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.
Packaging
1 kg in poly drum
5, 25, 100 g in poly bottle
Related Categories
Analytical Reagents, Analytical/Chromatography, Capillary Electrophoresis, Chelation/Complexation Compounds, Chemical Synthesis,
Chiral Mobile Phase Additives, Cyclodextrins, Synthetic Reagents
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