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Description_x000D_
Biochem/physiol Actions_x000D_
Interleukin-2 (IL-2), a cytokine, enhances Th (T helper) cell differentiation and effector responses. In addition, it helps in immune tolerance. IL-2 binds to the high affinity receptor, formed of IL2RA (interleukin 2 receptor subunit α), IL2RB (interleukin 2 receptor subunit β) and γ-chain. Polymorphism in IL2RA is associated with multiple sclerosis. Null mutation in IL2RA results in immune dysregulation._x000D_
Physical form_x000D_
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin._x000D_
Analysis Note_x000D_
The bioactivity is measured by its ability to inhibit the IL-2-dependent proliferation of a human megakaryocytic leukemic cell line, M07e.
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