Description General description Highly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+) and more effective than antibiotic A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, with intense UV absorption. In contrast to A23187, it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines. Often used in cell activation experiments when calcium dose-response data is not required. Useful in cell activation experiments when calcium dose-response data are not required. Also available as a 10 mM solution in DMSO (Cat. No. 407953). Packaging 1 mg in Plastic ampoule 10 mg in Plastic ampoule 5 mg in Glass bottle Packaged under inert gas 25 mg in Glass bottle Biochem/physiol Actions Cell permeable: no Primary Target Useful in cell activation experiments Product does not compete with ATP. Reversible: no Warning Toxicity: Harmful (C) Other Notes Dupuy d′Angeac, A., et al. 1993. J. Cell Physiol.154, 44. Lee, H.C. 1993. J. Biol. Chem.268, 293.