Description_x000D_ General description_x000D_ Ivermectin is a macro-cyclic lactone, derived from avermectin. It functions as an antiparasitic agent. Ivermectin is used against gastrointestinal roundworms, lungworms, mites and lice. It is used to treat onchocerciasis, strongyloidiasis, ascariasis and filariases._x000D_ Application_x000D_ Ivermectin has been used:_x000D_ • in Caenorhabditis elegans fecundity assay_x000D_ • in larval development test_x000D_ • to measure in vivo topical acaricide activity of compounds in rats_x000D_ • to assess its acute and chronic effects to zebrafish_x000D_ • in percutaneous drug injection method to treat cystic echinococcosis_x000D_ • in liquid chromatography with fluorescence detection method_x000D_ Packaging_x000D_ 1 g in poly bottle_x000D_ 250 mg in poly bottle_x000D_ Biochem/physiol Actions_x000D_ Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels._x000D_ Features and Benefits_x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here._x000D_ This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here._x000D_ Other Notes_x000D_ Primarily ivermectin B1a._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC