KETOPROFEN

Description_x000D_ General description_x000D_ Ketoprofen belongs to the class of 2-arylpropionic acid._x000D_ Application_x000D_ Ketoprofen has been used:_x000D_ • as sample to analyse the effects of long storage period by chromatographic and microscopic techniques_x000D_ • as a nonselective COX inhibitor to inject subcutaneously in rats to study its effect on stress/methamphetamine hydrochloride-induced changes in occludin, claudin-5 and COX-2 protein immunoreactivity, truncation of β-dystroglycan, brain water content and fluorescein isothiocyanate-dextran extravasation_x000D_ • in phosphate buffer to study its ability to inhibit heat-induced denaturation of albumin_x000D_ Biochem/physiol Actions_x000D_ It serves as an efficient drug to treat ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. It also has antipyretic and analgesic effects. Ketoprofen prevents the action of prostaglandin synthetase._x000D_ Non-steroidal anti-inflammatory compound that is selective for COX-1._x000D_ Features and Benefits_x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC