Description_x000D_ General description_x000D_ PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade._x000D_ To request the Enhanced Quality Product Documentation for this product, please contact Customer Support and select ‘Product Documentation’. Please note that access to the Enhanced Quality Product Documentation for this product requires a confidentiality disclosure agreement._x000D_ Application_x000D_ L-Histitidine is an essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies._x000D_ Biochem/physiol Actions_x000D_ Precursor of histamine by action of histidine decarboxylase.