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Description_x000D_
General description_x000D_
LC20 is the myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. LC20 protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for LC20 and the deduced 172-amino acid protein is highly conserved, with only 3 differences between the human and chicken proteins. Light chain phosphorylation causes the folded monomeric form of myosin to extend and assemble into filaments. This observation established the involvement of the LC20 in conformational transitions of smooth muscle myosin._x000D_
Physical form_x000D_
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol._x000D_
Preparation Note_x000D_
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
- Related Categories Calcium-associated Proteins, Cell Biology, Cell Signaling and Neuroscience, Peptides and Proteins, Proteins for Cell BiologyMore... biological source
