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LEUPEPTIN HEMISULFATE FROM MICROBIAL
Кат. №: L2884-25MG
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Description_x000D_
Packaging_x000D_
5, 10, 25, 50, 100, 250 mg in glass bottle_x000D_
Biochem/physiol Actions_x000D_
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)_x000D_
Analysis Note_x000D_
Leupeptin gives multiple peaks on HPLC due to equilibria among three forms in solution. Purity determined using three main peaks. Majority of contaminating peptide is racemized leupeptin.
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