Description_x000D_ General description_x000D_ Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage, hematopoietic cell formation and mesoderm patterning. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors. Among the BMPs, BMP-4 has major role in mammalian hematopoiesis, formation of mesoderm, myogenesis and differentiation of embryonic stem cells. BMP-4 signaling involves activation of major pathways such as Hedgehog and Wnt signaling.. Monoclonal Anti-BMP-4 recognizes human BMP-4. The antibody shows ~5% cross reactivity with recombinant human BMP-2, recombinant mouse BMP RIA, and recombinant mouse BMP-RIB._x000D_ Specificity_x000D_ The antibody shows approximately 5% cross-reactivity with recombinant human BMP-2, mouse BMP RIA, and mouse BMP RIB._x000D_ Immunogen_x000D_ recombinant monomeric human BMP-4 expressed in NSO cells._x000D_ Application_x000D_ The antibody is suitable for neutralization assays at a working concentration of 1-3 μg/ml (ND50)._x000D_ Physical form_x000D_ Lyophilized from a 0.2 μm filtered solution in in phosphate buffered saline with 5% trehalose._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Preparation Note_x000D_ Purified using protein G.