MOUSE MYELOMA PROTEIN-IGG1, KAPPA (MOPC&

Description_x000D_ Application_x000D_ IgG1, κ from murine myeloma has been used in the in situ hybridization experiments with bulbar conjunctiva sections, and immunohistochemistry of cattle and artery tissues._x000D_ IgG1, κ from murine myeloma was used immunofluorescence of leukocytes at a concentration of 50 μg/ml. It was used as a standard in ELISA and as exchange antibody in centrifugal gel filtration._x000D_ Biochem/physiol Actions_x000D_ IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections._x000D_ IgG1 has a molecular weight of 146 kDa and is an abundantly expressed IgG subclass. IgG1 deficiencies contribute to overall decrease in total IgG levels resulting in hypogammaglobulinemia. IgG1 promotes bacterial phagocytosis and mediates vaccine-induced protection from infection. The ratio of IgG2a to IgG1 is crucial for the immune response against Leishmania tropica infection. It has high binding affinity towards the Fcγ receptors (FcγR). High levels of IgG1-κ antibodies is associated with the pathology of glomerulonephritis._x000D_ Physical form_x000D_ Solution in 0.02 M Tris buffered saline, pH 8.0, containing 0.02% sodium azide_x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.