NOTCH-2,MOUSE

Description_x000D_ General description_x000D_ Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins._x000D_ Physical form_x000D_ Lyophilized with PBS._x000D_ Reconstitution_x000D_ Reconstitute with sterile water to 1 mg/mL.