Description_x000D_ Application_x000D_ Antimicrobial against Pneumocystis carinii._x000D_ Pentamidine isethionate salt has been used:_x000D_ • as a positive control for anti-leishmanial, anti-plasmodial and cytotoxic assays_x000D_ • as a prototypical compound to analyse the inhibitor effect on human ether-a-go-go-related gene (HERG) K+ channel trafficking_x000D_ • as an anti-leishmanial agent in promastigotes_x000D_ Packaging_x000D_ 1 g in glass bottle_x000D_ 100, 250 mg in glass bottle_x000D_ 25 mg in poly bottle_x000D_ Biochem/physiol Actions_x000D_ Neuroprotective; inhibits constitutive nitric oxide synthase in the brain; NMDA glutamate receptor antagonist._x000D_ Pentamidine isethionate is used as a second line drug for leishmaniasis._x000D_ Features and Benefits_x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ This compound was developed by Celgene. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC