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Description_x000D_
General description_x000D_
Pentylenetetrazole (PTZ) is a tetrazole derivative and inhibitor of the γ aminobutyric acid (GABAA) and its receptor complex. PTZ is a convulsing agent used for inducing seizures. It can traverse the blood-brain barrier._x000D_
Application_x000D_
Pentylenetetrazole has been used to induce seizures in zebra fish larvae, mice, and male wistar rats._x000D_
Packaging_x000D_
25, 50, 100 g in poly bottle_x000D_
Biochem/physiol Actions_x000D_
Pentylenetetrazole is a non-specific central nervous system (CNS) stimulant and convulsant. PTZ induces oxidative stress and increases cortical malondialdehyde content and affects hippocampus, resulting in seizures._x000D_
Features and Benefits_x000D_
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_
Legal Information_x000D_
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
- Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Neurobiology, Neuroscience, P-PH, Pharmacologicals, StimulantsMore... Quality Level
