PENTYLENETETRAZOLE

Description_x000D_ General description_x000D_ Pentylenetetrazole (PTZ) is a tetrazole derivative and inhibitor of the γ aminobutyric acid (GABAA) and its receptor complex. PTZ is a convulsing agent used for inducing seizures. It can traverse the blood-brain barrier._x000D_ Application_x000D_ Pentylenetetrazole has been used to induce seizures in zebra fish larvae, mice, and male wistar rats._x000D_ Packaging_x000D_ 25, 50, 100 g in poly bottle_x000D_ Biochem/physiol Actions_x000D_ Pentylenetetrazole is a non-specific central nervous system (CNS) stimulant and convulsant. PTZ induces oxidative stress and increases cortical malondialdehyde content and affects hippocampus, resulting in seizures._x000D_ Features and Benefits_x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC