PROSTAGLANDIN I2 SODIUM SALT

Description_x000D_ Application_x000D_ Prostaglandin I2 sodium salt has been used:_x000D_ • in the preparation of stock solution for platelet washing procedure_x000D_ • as supplement in platelet-rich-plasma, for platelet preparation_x000D_ • to prevent platelet activation_x000D_ Packaging_x000D_ 1, 5, 10 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Prostacyclin is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A2 and stimulating platelet adenylyl cyclase. Nitric oxide is also produced in vascular endothelium where it inhibits platelet aggregation, regulates inducible cyclooxygenase production, and may work synergistically with prostacyclin to attenuate the thrombotic process. Prostacyclin is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract._x000D_ Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.