Салиномицин

Salinomycin is a carboxylic polyether ionophore isolated from Streptomyces albus that has been widely used as an agricultural antibiotic to prevent coccidiosis in poultry. Salinomycin was first isolated in 1974 by the research division of Kaken Chemical Co. in Tokyo Japan. Salinomycin effects cell mambrane permeability by increasing cation movement across cell membranes through exchange-diffusion, resulting in altered gradients due to a lack of control of ion permeability. This effect allows ions (K+, Na+, Ca+, Mg2+) to accumulate inside the cell, reaching toxic levels. Salinomycin is effective against gram-positive bacteria including mycobacteria, some filamentous fungi, and coccidia. Salinomycin has been shown to induce apoptosis in a variety of cancer cell lines and to inhibit multidrug resistance protein 1. TOKU-E offers two forms of salinomycin: salinomycin (S001) and salinomycin sodium (S002). Salinomycin is slightly soluble in methanol at 10 mg/mL. Salinomycin sodium is freely soluble in water. This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions. synonyms: Coxistal, Coxistac Fangyuan Xie et al. used salinomycin from TOKU-E to study its efficacy toward liver cancer cells when used in combination with chloroquine. Read more here: "Codelivery of salinomycin and chloroquine by liposomes enables synergistic antitumor activity in vitro."