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Description_x000D_
Application_x000D_
TBB was used to study casein kinase 2-dependent phosphorylation of DNA damage mediator protein MDC1._x000D_
Packaging_x000D_
10 mg in glass bottle_x000D_
Biochem/physiol Actions_x000D_
TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP. TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells._x000D_
TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 900 nM and 1.6 mM, using rat liver and recombinant human CK2, respectively)._x000D_
Features and Benefits_x000D_
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_
Legal Information_x000D_
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
- Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Casein Kinase (CK), Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, TMore... Quality Level