Description_x000D_ Application_x000D_ Thiamet G has been used as an O-GlcNAcase inhibitor:_x000D_ • to treat human embryonic kidney 293 cells in order to study its effect on Wnt/beta-catenin signalling_x000D_ • to treat lytically-replicating producer_x000D_ • to incubate mice (C57BL/6) aortic segments to increase global O-GlcNAc levels_x000D_ Packaging_x000D_ 5, 25 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Thiamet G is a potent inhibitor of the enzyme O-GlcNAcase (Ki = 21 nM). The compound is orally bioavailable and crosses the blood brain barrier. Thiamet G leads to an increase in O-GlcNAc-modified proteins in cell-based and in vivo assay systems, and reduces levels of phosphorylated Tau protein in rat cortex and hippocampus.