Tylosin B, EvoPure® is a highly purified form of tylosin B or desmycosin. Tylosin B is a metabolite of tylosin A and forms in acidic media. Tylosin is a macrolide antibiotic that was originally isolated from Streptomyces fradiae by the Lilly Research Laboratories in 1961 from a soil sample collected in Thailand. Tylosin is a mixture of four macrolide antibiotics, the main component of the mixture (> 80%) is tylosin A; tylosin B (desmycosin), tylosin C (macrocin), and tylosin D (relomycin) may also be present. Tylosin has broad spectrum bacteriostatic activity against gram-positive bacteria and mycoplasma, but much less activity against most gram-negative bacteria and fungi. Tylosin, like other Macrolide antibiotics, is a bacteriostatic compound that reversibly bind to the 23S rRNA in the 50S (L27 protein) ribosome subunit and inhibit mRNA-directed protein synthesis. Tylosin has been used to study protein synthesis, abscess prevention in cattle, and Mycoplasma infections. For more Tylosin products click here.