Description General description A steroidal alkaloid that structurally resembles Cyclopamine (Cat. No. 239803), but lacks the capacity to inhibit Sonic Hedgehog (Shh) signaling. Reported to be non-teratogenic. Useful as a negative control. A steroidal alkaloid that structurally resembles Cyclopamine (Cat. No. 239803), but lacks the capacity to inhibit Shh (Sonic Hedgehog) signaling. Reported to be non-teratogenic. Packaging 25 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Primary Target Negative control for Shh (Sonic Hedgehog) signaling Product does not compete with ATP. Reversible: no Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Preparation Note Slight warming may be required to achieve complete solubilization. Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Other Notes Berman, D.M., et al. 2003. Nature,425, 846. Thayer, S.P., et al. 2003. Nature,425, 851. Watkins, D.N., et al. 2003. Nature422, 313. Cooper, M.K., et al. 1998. Science280, 1603. Kim, S.K. and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA95, 13036.